Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC6879341 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Wu Yingying Y Qin Junying J Li Fubing F Yang Chuanyu C Li Zhen Z Zhou Zhongmei Z Zhang Hailin H Li Yunxi Y Wang Xinye X Liu Rong R Tao Qian Q Chen Wenlin W Chen Ceshi C
The Journal of biological chemistry 20191017 47
The Krüppel-like factor 5 (KLF5) transcription factor is highly expressed in basal type breast cancer and promotes breast cancer cell proliferation, survival, migration, and tumorigenesis. KLF5 protein stability is regulated by ubiquitination. In this study, ubiquitin-specific protease 3 (USP3) was identified as a new KLF5 deubiquitinase by genome-wide siRNA library screening. We demonstrated that USP3 interacts with KLF5 and stabilizes KLF5 via deubiquitination. USP3 knockdown inhibits breast c ...[more]