Caesarean section, but not induction of labour, is associated with major changes in cord blood metabolome.
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ABSTRACT:
SUBMITTER: Marchioro L
PROVIDER: S-EPMC6879512 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Caesarean section, but not induction of labour, is associated with major changes in cord blood metabolome.
Marchioro Linda L Shokry Engy E Geraghty Aisling A AA O'Brien Eileen C EC Uhl Olaf O Koletzko Berthold B McAuliffe Fionnuala M FM
Scientific reports 20191126 1
The physiology of how prelabour caesarean section (PCS) and induction of labour (IOL) in comparison to spontaneous vaginal delivery (SVD) has not been fully clarified yet. We measured 201 cord blood (CB) phospholipids and energy metabolites via LC/MS-MS in 109 newborns from the ROLO Kids study; metabolites were compared across the three parturition groups via linear mixed models with correction for multiple testing. In comparison to SVD, PCS babies had lower non-esterified fatty acids (NEFA), in ...[more]
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Project description:The new expert recommendation from the Austrian Society of Obstetrics and Gynaecology (OEGGG) comprises an interpretation and summary of guidelines from the leading specialist organisations worldwide (RCOG, ACOG, SOGC, CNGOF, WHO, NIH, NICE, UpToDate). In essence it outlines alternatives to the direct pathway to elective repeat caesarean section (ERCS). In so doing it aligns with international trends, according to which a differentiated, individualised clinical approach is recommended that considers benefits and risks to both mother and child, provides detailed counselling and takes the patient's wishes into account. In view of good success rates (60-85?%) for vaginal birth after caesarean section (VBAC) the consideration of predictive factors during antenatal birth planning has become increasingly important. This publication provides a compact management recommendation for the majority of standard clinical situations. However it cannot and does not claim to cover all possible scenarios. The consideration of all relevant factors in each individual case, and thus the ultimate decision on mode of delivery, remains the discretion and responsibility of the treating obstetrician.
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