Ontology highlight
ABSTRACT:
SUBMITTER: Su N
PROVIDER: S-EPMC6879534 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Su Nannan N Byrd Alicia K AK Bharath Sakshibeedu R SR Yang Olivia O Jia Yu Y Tang Xuhua X Ha Taekjip T Raney Kevin D KD Song Haiwei H
Nature communications 20191126 1
Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA, but the mechanism by which Pif1 unwinds forked dsDNA remains elusive. Here we report the structure of Bacteroides sp Pif1 (BaPif1) in complex with a symmetrical double forked dsDNA. Two interacting BaPif1 molecules are bound to each fork of the partially unwound dsDNA, and interact with the 5' arm and 3' ss/dsDNA respectively. Each of the two BaPif1 molecules is an active helicase and their interac ...[more]