Thromboinflammatory changes in plasma proteome of pregnant women with PCOS detected by quantitative label-free proteomics.
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ABSTRACT:
SUBMITTER: Arffman RK
PROVIDER: S-EPMC6879536 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Thromboinflammatory changes in plasma proteome of pregnant women with PCOS detected by quantitative label-free proteomics.
Arffman R K RK Saraswat M M Joenväärä S S Khatun M M Agarwal R R Tohmola T T Sundström-Poromaa I I Renkonen R R Piltonen T T TT
Scientific reports 20191126 1
Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder of fertile-aged women. Several adverse pregnancy outcomes and abnormalities of the placenta have been associated with PCOS. By using quantitative label-free proteomics we investigated whether changes in the plasma proteome of pregnant women with PCOS could elucidate the mechanisms behind the pathologies observed in PCOS pregnancies. A total of 169 proteins with ≥2 unique peptides were detected to be differentially expr ...[more]
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