Ontology highlight
ABSTRACT:
SUBMITTER: Cantarelli C
PROVIDER: S-EPMC6879550 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Cantarelli Chiara C Guglielmo Chiara C Hartzell Susan S Salem Fadi El FE Andrighetto Sofia S Gazivoda Victor P VP Fiaccadori Enrico E La Manna Gaetano G Zaza Gianluigi G Leventhal Jeremy J Tassiulas Ioannis I Cravedi Paolo P
Frontiers in immunology 20191120
Current guidelines encourage administering pneumococcal vaccine Prevnar-13 to patients with lupus, but whether such vaccinations affect disease severity is unclear. To address this issue, we treated 3-month-old MRL-<i>lpr</i> mice, that spontaneously develop a lupus-like syndrome, with Prevnar-13 or vehicle control. After 3 months, we quantified circulating anti-Pneumococcal polysaccharide capsule (PPS) antibodies and signs of disease severity, including albuminuria, renal histology and skin sev ...[more]