Ontology highlight
ABSTRACT:
SUBMITTER: Low L
PROVIDER: S-EPMC6879612 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Nature communications 20191126 1
Accumulation of mutant p53 proteins is frequently found in a wide range of cancers. While conventional antibodies fail to target intracellular proteins, proteosomal degradation results in the presentation of p53-derived peptides on the tumour cell surface by class I molecules of the major histocompatibility complex (MHC). Elevated levels of such p53-derived peptide-MHCs on tumour cells potentially differentiate them from healthy tissues. Here, we report the engineering of an affinity-matured hum ...[more]