Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network.
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ABSTRACT:
SUBMITTER: Haupt S
PROVIDER: S-EPMC6879765 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network.
Haupt Sue S Caramia Franco F Herschtal Alan A Soussi Thierry T Lozano Guillermina G Chen Hu H Liang Han H Speed Terence P TP Haupt Ygal Y
Nature communications 20191126 1
The disproportionately high prevalence of male cancer is poorly understood. We tested for sex-disparity in the functional integrity of the major tumor suppressor p53 in sporadic cancers. Our bioinformatics analyses expose three novel levels of p53 impact on sex-disparity in 12 non-reproductive cancer types. First, TP53 mutation is more frequent in these cancers among US males than females, with poorest survival correlating with its mutation. Second, numerous X-linked genes are associated with p5 ...[more]
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