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An intrinsically disordered proteins community for ELIXIR.


ABSTRACT: Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled "An intrinsically disordered protein user community proposal for ELIXIR" held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination; integration of IDP data into the ELIXIR Core Data Resources; and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.

SUBMITTER: Davey NE 

PROVIDER: S-EPMC6880265 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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An intrinsically disordered proteins community for ELIXIR.

Davey Norman E NE   Babu M Madan MM   Blackledge Martin M   Bridge Alan A   Capella-Gutierrez Salvador S   Dosztanyi Zsuzsanna Z   Drysdale Rachel R   Edwards Richard J RJ   Elofsson Arne A   Felli Isabella C IC   Gibson Toby J TJ   Gutmanas Aleksandras A   Hancock John M JM   Harrow Jen J   Higgins Desmond D   Jeffries Cy M CM   Le Mercier Philippe P   Mészáros Balint B   Necci Marco M   Notredame Cedric C   Orchard Sandra S   Ouzounis Christos A CA   Pancsa Rita R   Papaleo Elena E   Pierattelli Roberta R   Piovesan Damiano D   Promponas Vasilis J VJ   Ruch Patrick P   Rustici Gabriella G   Romero Pedro P   Sarntivijai Sirarat S   Saunders Gary G   Schuler Benjamin B   Sharan Malvika M   Shields Denis C DC   Sussman Joel L JL   Tedds Jonathan A JA   Tompa Peter P   Turewicz Michael M   Vondrasek Jiri J   Vranken Wim F WF   Wallace Bonnie Ann BA   Wichapong Kanin K   Tosatto Silvio C E SCE  

F1000Research 20191015


Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop ti  ...[more]

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