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Testing an infection model to explain excess risk of preterm birth with long-term iron supplementation in a malaria endemic area.


ABSTRACT: BACKGROUND:In view of recent evidence from a randomized trial in Burkina Faso that periconceptional iron supplementation substantially increases risk of spontaneous preterm birth (

SUBMITTER: Brabin B 

PROVIDER: S-EPMC6880560 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Testing an infection model to explain excess risk of preterm birth with long-term iron supplementation in a malaria endemic area.

Brabin Bernard B   Tinto Halidou H   Roberts Stephen A SA  

Malaria journal 20191126 1


<h4>Background</h4>In view of recent evidence from a randomized trial in Burkina Faso that periconceptional iron supplementation substantially increases risk of spontaneous preterm birth (< 37 weeks) in first pregnancies (adjusted relative risk = 2.22; 95% CI 1.39-3.61), explanation is required to understand potential mechanisms, including progesterone mediated responses, linking long-term iron supplementation, malaria and gestational age.<h4>Methods</h4>The analysis developed a model based on a  ...[more]

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