Impact of prior stroke on major clinical outcome in chronic kidney disease: the Salford kidney cohort study.

ABSTRACT: BACKGROUND:Chronic kidney disease (CKD) is an independent risk factor for stroke in the general population. The impact of prior stroke on major clinical outcomes in CKD populations is poorly characterised. METHODS:The Salford Kidney Study is a UK prospective cohort of more than 3000 patients recruited since 2002 and followed until March 2018. Multivariable Cox regression examined associations of stroke at two time points; cohort inception, and at dialysis initiation, with risks of death, non-fatal cardiovascular events (NFCVE) and end stage renal disease (ESRD). RESULTS:277 (9.1%) of 3060 patients suffered a prior stroke and this was associated with mortality, ESRD and future NFCVE after cardiovascular risk factor adjustments. Median survival for prior stroke patients was 40 months vs 77 m

SUBMITTER: Tollitt J 

PROVIDER: S-EPMC6880597 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature