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First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism.

ABSTRACT: We developed methods for the preparation of hyperpolarized (HP) sterile [2-13C]pyruvate to test its feasibility in first-ever human NMR studies following FDA-IND & IRB approval. Spectral results using this MR stable-isotope imaging approach demonstrated the feasibility of investigating human cerebral energy metabolism by measuring the dynamic conversion of HP [2-13C]pyruvate to [2-13C]lactate and [5-13C]glutamate in the brain of four healthy volunteers. Metabolite kinetics, signal-to-noise (SNR) and area-under-curve (AUC) ratios, and calculated [2-13C]pyruvate to [2-13C]lactate conversion rates (kPL) were measured and showed similar but not identical inter-subject values. The kPL measurements were equivalent with prior human HP [1-13C]pyruvate measurements.

SUBMITTER: Chung BT 

PROVIDER: S-EPMC6880930 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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We developed methods for the preparation of hyperpolarized (HP) sterile [2-<sup>13</sup>C]pyruvate to test its feasibility in first-ever human NMR studies following FDA-IND & IRB approval. Spectral results using this MR stable-isotope imaging approach demonstrated the feasibility of investigating human cerebral energy metabolism by measuring the dynamic conversion of HP [2-<sup>13</sup>C]pyruvate to [2-<sup>13</sup>C]lactate and [5-<sup>13</sup>C]glutamate in the brain of four healthy volunteers  ...[more]