Role of a 19S Proteasome Subunit- PSMD10^Gankyrin in Neurogenesis of Human Neural Progenitor Cells.

ABSTRACT: PSMD10^Gankyrin, a proteasome assembly chaperone, is a widely known oncoprotein which aspects many hall mark properties of cancer. However, except proteasome assembly chaperon function its role in normal cell function remains unknown. To address this issue, we induced PSMD10^Gankyrin overexpression in HEK293 cells and the resultant large-scale changes in gene expression profile were analyzed. We constituted networks from microarray data of these differentially expressed genes and carried out extensive topological analyses. The overrecurring yet consistent theme that appeared throughout analysis using varied network metrics is that all genes and interactions identified as important would be involved in neurogenesis and neuronal development. Intrigued we tested the possib

SUBMITTER: Sahu I 

PROVIDER: S-EPMC6881037 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature