Single-cell transcriptomic evidence for dense intracortical neuropeptide networks.
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ABSTRACT:
SUBMITTER: Smith SJ
PROVIDER: S-EPMC6881117 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Single-cell transcriptomic evidence for dense intracortical neuropeptide networks.
Smith Stephen J SJ Sümbül Uygar U Graybuck Lucas T LT Collman Forrest F Seshamani Sharmishtaa S Gala Rohan R Gliko Olga O Elabbady Leila L Miller Jeremy A JA Bakken Trygve E TE Rossier Jean J Yao Zizhen Z Lein Ed E Zeng Hongkui H Tasic Bosiljka B Hawrylycz Michael M
eLife 20191111
Seeking new insights into the homeostasis, modulation and plasticity of cortical synaptic networks, we have analyzed results from a single-cell RNA-seq study of 22,439 mouse neocortical neurons. Our analysis exposes transcriptomic evidence for dozens of molecularly distinct neuropeptidergic modulatory networks that directly interconnect all cortical neurons. This evidence begins with a discovery that transcripts of one or more neuropeptide precursor (NPP) and one or more neuropeptide-selective G ...[more]
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