Ontology highlight
ABSTRACT:
SUBMITTER: Morgan PJ
PROVIDER: S-EPMC6881145 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Morgan Peter James PJ Bourboulou Romain R Filippi Caroline C Koenig-Gambini Julie J Epsztein Jérôme J
eLife 20191127
In area CA1 of the hippocampus, the selection of place cells to represent a new environment is biased towards neurons with higher excitability. However, different environments are represented by orthogonal cell ensembles, suggesting that regulatory mechanisms exist. Activity-dependent plasticity of intrinsic excitability, as observed in vitro, is an attractive candidate. Here, using whole-cell patch-clamp recordings of CA1 pyramidal neurons in anesthetized rats, we have examined how inducing the ...[more]