Ontology highlight
ABSTRACT:
SUBMITTER: Beckmann JF
PROVIDER: S-EPMC6881146 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Beckmann John Frederick JF Sharma Gagan Deep GD Mendez Luis L Chen Hongli H Hochstrasser Mark M
eLife 20191127
Intracellular <i>Wolbachia</i> bacteria manipulate arthropod reproduction to promote their own inheritance. The most prevalent mechanism, cytoplasmic incompatibility (CI), traces to a <i>Wolbachia</i> deubiquitylase, CidB, and CidA. CidB has properties of a toxin, while CidA binds CidB and rescues embryonic viability. CidB is also toxic to yeast where we identified both host effects and high-copy suppressors of toxicity. The strongest suppressor was karyopherin-α, a nuclear-import receptor; this ...[more]