Ontology highlight
ABSTRACT:
SUBMITTER: Lehmann M
PROVIDER: S-EPMC6881173 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Science advances 20191127 11
Clathrin-mediated endocytosis, an essential process for plasma membrane homeostasis and cell signaling, is characterized by stunning heterogeneity in the size and lifetime of clathrin-coated endocytic pits (CCPs). If and how CCP growth and lifetime are coupled and how this relates to their physiological function are unknown. We combine computational modeling, automated tracking of CCP dynamics, electron microscopy, and functional rescue experiments to demonstrate that CCP growth and lifetime are ...[more]