Ontology highlight
ABSTRACT:
SUBMITTER: Prestel A
PROVIDER: S-EPMC6881253 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Prestel Andreas A Wichmann Nanna N Martins Joao M JM Marabini Riccardo R Kassem Noah N Broendum Sebastian S SS Otterlei Marit M Nielsen Olaf O Willemoës Martin M Ploug Michael M Boomsma Wouter W Kragelund Birthe B BB
Cellular and molecular life sciences : CMLS 20190527 24
Proliferating cell nuclear antigen (PCNA) is a cellular hub in DNA metabolism and a potential drug target. Its binding partners carry a short linear motif (SLiM) known as the PCNA-interacting protein-box (PIP-box), but sequence-divergent motifs have been reported to bind to the same binding pocket. To investigate how PCNA accommodates motif diversity, we assembled a set of 77 experimentally confirmed PCNA-binding proteins and analyzed features underlying their binding affinity. Combining NMR spe ...[more]