Ontology highlight
ABSTRACT:
SUBMITTER: Chung J
PROVIDER: S-EPMC6881322 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Chung Jihwa J Kim Kyoung Hwa KH An Shung Hyun SH Lee Sunmi S Lim Byung-Kwan BK Kang Sang Won SW Kwon Kihwan K
Experimental & molecular medicine 20191127 11
Endothelial mechanotransduction by fluid shear stress (FSS) modulates endothelial function and vascular pathophysiology through mechanosensors on the cell membrane. The coxsackievirus and adenovirus receptor (CAR) is not only a viral receptor but also a component of tight junctions and plays an important role in tissue homeostasis. Here, we demonstrate the expression, regulatory mechanism, and role of CAR in vascular endothelial cells (ECs) under FSS conditions. Disturbed flow increased, whereas ...[more]