Ontology highlight
ABSTRACT:
SUBMITTER: Kannan AK
PROVIDER: S-EPMC6881359 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Kannan Arun K AK Su Zhi Z Gauvin Donna M DM Paulsboe Stephanie E SE Duggan Ryan R Lasko Loren M LM Honore Prisca P Kort Michael E ME McGaraughty Steve P SP Scott Victoria E VE Gauld Stephen B SB
Scientific reports 20191127 1
Foxp3<sup>+</sup> regulatory T cells (Tregs) represent a major fraction of skin resident T cells. Although normally protective, Tregs have been shown to produce pro-inflammatory cytokines in human diseases, including psoriasis. A significant hurdle in the Treg field has been the identification, or development, of model systems to study this Treg plasticity. To overcome this gap, we analyzed skin resident Tregs in a mouse model of IL-23 mediated psoriasiform dermatitis. Our results demonstrate th ...[more]