Ontology highlight
ABSTRACT:
SUBMITTER: Scantlebery AML
PROVIDER: S-EPMC6881402 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Scantlebery Angelique M L AML Ochodnicky Peter P Kors Lotte L Rampanelli Elena E Butter Loes M LM El Boumashouli Chaima C Claessen Nike N Teske Gwen J GJ van den Bergh Weerman Marius A MA Leemans Jaklien C JC Roelofs Joris J T H JJTH Florquin Sandrine S
Scientific reports 20191127 1
Obesity has become a worldwide health crisis and is associated with a plethora of comorbidities. The multi-organ effects of obesity have been linked to ectopic lipid accumulation. Thus, there is an urgent need to tackle the obesity crisis by developing effective lipid-lowering therapies. 2-hydroxypropyl-β-Cyclodextrin (2HP-β-CD) has been previously shown to reduce lysosomal cholesterol accumulation in a murine model of Niemann Pick Type C (NPC) disease. Using a murine model of Western diet-induc ...[more]