Ontology highlight
ABSTRACT:
SUBMITTER: Singh J
PROVIDER: S-EPMC6881452 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Singh Jaswinder J Hanson Jack J Paliwal Kuldip K Zhou Yaoqi Y
Nature communications 20191127 1
The majority of our human genome transcribes into noncoding RNAs with unknown structures and functions. Obtaining functional clues for noncoding RNAs requires accurate base-pairing or secondary-structure prediction. However, the performance of such predictions by current folding-based algorithms has been stagnated for more than a decade. Here, we propose the use of deep contextual learning for base-pair prediction including those noncanonical and non-nested (pseudoknot) base pairs stabilized by ...[more]