Two-stage adaptive enrichment design for testing an active factor.
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ABSTRACT:
SUBMITTER: Ding AA
PROVIDER: S-EPMC6881517 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Two-stage adaptive enrichment design for testing an active factor.
Ding A Adam AA Wu Samuel S SS Dean Natalie E NE Zahigian Rachel S RS
Journal of biopharmaceutical statistics 20190528 1
We propose an adaptive enrichment approach to test an active factor, which is a factor whose effect is non-zero in at least one subpopulation. We implement a two-stage play-the-winner design where all subjects in the second stage are enrolled from the subpopulation that has the highest observed effect in the first stage. We recommend a weighted Fisher's combination of the most powerful test for each stage, respectively: the first stage Hotelling's test and the second stage noncentral chi-square ...[more]
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