Ontology highlight
ABSTRACT:
SUBMITTER: Friggeri L
PROVIDER: S-EPMC6881533 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Friggeri Laura L Hargrove Tatiana Y TY Wawrzak Zdzislaw Z Guengerich F Peter FP Lepesheva Galina I GI
Journal of medicinal chemistry 20191111 22
Sterol 14α-demethylases (CYP51) are the cytochrome P450 enzymes required for biosynthesis of sterols in eukaryotes, the major targets for antifungal agents and prospective targets for treatment of protozoan infections. Human CYP51 could be and, for a while, was considered as a potential target for cholesterol-lowering drugs (the role that is now played by statins, which are also in clinical trials for cancer) but revealed high intrinsic resistance to inhibition. While microbial CYP51 enzymes are ...[more]