Environmental boundary conditions for the origin of life converge to an organo-sulfur metabolism.
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ABSTRACT:
SUBMITTER: Goldford JE
PROVIDER: S-EPMC6881557 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Environmental boundary conditions for the origin of life converge to an organo-sulfur metabolism.
Goldford Joshua E JE Hartman Hyman H Marsland Robert R Segrè Daniel D
Nature ecology & evolution 20191111 12
It has been suggested that a deep memory of early life is hidden in the architecture of metabolic networks, whose reactions could have been catalyzed by small molecules or minerals before genetically encoded enzymes. A major challenge in unravelling these early steps is assessing the plausibility of a connected, thermodynamically consistent proto-metabolism under different geochemical conditions, which are still surrounded by high uncertainty. Here we combine network-based algorithms with physic ...[more]
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