CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging.
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ABSTRACT:
SUBMITTER: Rui YF
PROVIDER: S-EPMC6881574 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging.
Rui Yun-Feng YF Chen Min-Hao MH Li Ying-Juan YJ Xiao Long-Fei LF Geng Peng P Wang Pei P Xu Zheng-Yuan ZY Zhang Xuan-Pu XP Dai Guang-Chun GC
Stem cells international 20191111
Aged tendon-derived stem/progenitor cells (TSPCs) lead to age-related tendon disorders and impair tendon healing. However, the underlying molecular mechanisms of TSPC aging remain largely unknown. Here, we investigated the role of connective tissue growth factor (CTGF) in TSPC aging. CTGF protein and mRNA levels were markedly decreased in the aged TSPCs. Moreover, recombinant CTGF attenuates TSPC aging and restores the age-associated reduction of self-renewal and differentiation of TSPCs. In add ...[more]
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