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A comparison of clinical paediatric guidelines for hypotension with population-based lower centiles: a systematic review.


ABSTRACT: BACKGROUND:Different definitions exist for hypotension in children. In this study, we aim to identify evidence-based reference values for low blood pressure and to compare these with existing definitions for systolic hypotension. METHODS:We searched online databases until February 2019 (including MEDLINE, EMBASE, Web of Science) using a comprehensive search strategy to identify studies that defined age-related centiles (first to fifth centile) for non-invasive systolic blood pressure in healthy children ?12?years. For children >?12?years, the definition of Parshuram's early warning score agreed well, but the Advanced Paediatric Life Support definition was above the fifth centiles. CONCLUSIONS:The different clinical guidelines for low blood pressure show large variability and low to moderate agreement with population-based lower centiles. For children ?12?years, the Advanced Paediatric Life Support overestimates hypotension but Parshuram's cut-off for hypotension in the early warning score agrees well. Future studies should focus on developing reference values for hypotension for acutely ill children.

SUBMITTER: Hagedoorn NN 

PROVIDER: S-EPMC6882047 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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A comparison of clinical paediatric guidelines for hypotension with population-based lower centiles: a systematic review.

Hagedoorn Nienke N NN   Zachariasse Joany M JM   Moll Henriette A HA  

Critical care (London, England) 20191127 1


<h4>Background</h4>Different definitions exist for hypotension in children. In this study, we aim to identify evidence-based reference values for low blood pressure and to compare these with existing definitions for systolic hypotension.<h4>Methods</h4>We searched online databases until February 2019 (including MEDLINE, EMBASE, Web of Science) using a comprehensive search strategy to identify studies that defined age-related centiles (first to fifth centile) for non-invasive systolic blood press  ...[more]

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