Ontology highlight
ABSTRACT:
SUBMITTER: Goedecke L
PROVIDER: S-EPMC6882837 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Goedecke L L Bengoetxea X X Blaesse P P Pape H-C HC Jüngling K K
Scientific reports 20191128 1
Brain µ-opioid receptors (MOR) mediate reward and help coping with pain, social rejection, anxiety and depression. The dorsal midline thalamus (dMT) integrates visceral/emotional signals and biases behavior towards aversive or defensive states through projections to the amygdala. While a dense MOR expression in the dMT has been described, the exact cellular and synaptic mechanisms of µ-opioidergic modulation in the dMT-amygdala circuitry remain unresolved. Here, we hypothesized that MORs are imp ...[more]