Ontology highlight
ABSTRACT:
SUBMITTER: Umbricht CA
PROVIDER: S-EPMC6882876 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Umbricht Christoph A CA Köster Ulli U Bernhardt Peter P Gracheva Nadezda N Johnston Karl K Schibli Roger R van der Meulen Nicholas P NP Müller Cristina C
Scientific reports 20191128 1
In this study, it was aimed to investigate <sup>149</sup>Tb-PSMA-617 for targeted α-therapy (TAT) using a mouse model of prostate-specific membrane antigen (PSMA)-expressing prostate cancer. <sup>149</sup>Tb-PSMA-617 was prepared with >98% radiochemical purity (6 MBq/nmol) for the treatment of mice with PSMA-positive PC-3 PIP tumors. <sup>149</sup>Tb-PSMA-617 was applied at 1 × 6 MBq (Day 0) or 2 × 3 MBq (Day 0 & Day 1 or Day 0 & Day 3) and the mice were monitored over time until they had reache ...[more]