Ontology highlight
ABSTRACT:
SUBMITTER: Belkina AC
PROVIDER: S-EPMC6882880 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Belkina Anna C AC Ciccolella Christopher O CO Anno Rina R Halpert Richard R Spidlen Josef J Snyder-Cappione Jennifer E JE
Nature communications 20191128 1
Accurate and comprehensive extraction of information from high-dimensional single cell datasets necessitates faithful visualizations to assess biological populations. A state-of-the-art algorithm for non-linear dimension reduction, t-SNE, requires multiple heuristics and fails to produce clear representations of datasets when millions of cells are projected. We develop opt-SNE, an automated toolkit for t-SNE parameter selection that utilizes Kullback-Leibler divergence evaluation in real time to ...[more]