Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma.
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ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC6883075 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma.
Liu Huibin H Pu Yan Y Amina Quhai Q Wang Qiang Q Zhang Mengmeng M Song Jianzhong J Guo Jun J Mardan Mahmut M
Scientific reports 20191128 1
Adenylate kinase 2 (AK2), an isoenzyme of the AK family, may have momentous extra-mitochondrial functions, especially in tumourigenesis in addition to the well-known control of energy metabolism. In this study, we provided the first evidence that AK2 is overexpressed in lung adenocarcinoma. The positive expression of AK2 is associated with tumor progression, and poor survival in patients with pulmonary adenocarcinoma. Knockdown of AK2 could suppress proliferation, migration, and invasion as well ...[more]
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