Dataset Information

The Estimating effectiveness from efficacy taxonomy (EFFECT): A tool to estimate the real-world impact of health interventions.

ABSTRACT:

Aims

To develop and pilot test a taxonomy that empirically estimates health intervention effectiveness from efficacy data.

Methods

We developed a taxonomy to score health interventions across 11 items on a scale from 0-100. The taxonomy was pilot-tested in efficacy and effectiveness diabetes prevention studies identified in two separate systematic reviews; here, the face validity, inter-rater reliability and factor structure of the taxonomy were established. Random effects meta-analyses were used to obtain weight loss and diabetes incidence pooled effects across studies. These effects and taxonomy scores were used to down calibrate efficacy estimates to effectiveness estimates as follows: Efficacy effect*[Efficacy score/highest possible score].

Results

We scored 82 effectiveness lifestyle modification studies (mean score 49.2), 32 efficacy lifestyle modification studies (mean score 69.8) and 20 efficacy studies testing medications (mean score 77.4). The taxonomy had face validity and good inter-rater reliability (ICC?=?0.9 [0.87, 0.93]). The between-groups down calibrated weight loss estimate was similar to that observed in the effectiveness meta-analysis (1.7 and 1.8?kg, respectively). The down calibrated diabetes relative risk reduction was also similar to that observed in the effectiveness meta-analysis (30.6% over 2.7?years and 29% over 2?years, respectively).

Conclusions

The taxonomy is a promising tool to estimate the real-world impact of health interventions.

SUBMITTER: Galaviz KI

PROVIDER: S-EPMC6883153 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

The Estimating effectiveness from efficacy taxonomy (EFFECT): A tool to estimate the real-world impact of health interventions.

Galaviz Karla I KI Ali Mohammed K MK Haw Jeehea Sonya JS Magee Matthew James MJ Kowalski Alysse A Wei Jingkai J Straus Audrey A Weber Mary Beth MB Vos Theo T Murray Christopher C Narayan K M V KMV

Diabetes research and clinical practice 20190529

<h4>Aims</h4>To develop and pilot test a taxonomy that empirically estimates health intervention effectiveness from efficacy data.<h4>Methods</h4>We developed a taxonomy to score health interventions across 11 items on a scale from 0-100. The taxonomy was pilot-tested in efficacy and effectiveness diabetes prevention studies identified in two separate systematic reviews; here, the face validity, inter-rater reliability and factor structure of the taxonomy were established. Random effects meta-an ...[more]

PMID: 31152807

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Dataset Information

The Estimating effectiveness from efficacy taxonomy (EFFECT): A tool to estimate the real-world impact of health interventions.

Aims

Methods

Results

Conclusions

Publications

The Estimating effectiveness from efficacy taxonomy (EFFECT): A tool to estimate the real-world impact of health interventions.

Similar Datasets

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