Irradiation-Related Lymphopenia for Bone Metastasis from Hepatocellular Carcinoma.

ABSTRACT:

Background/aim

In the era of immunotherapy, treatment-related lymphopenia (TRL) is gaining attention. In this study, TRL was investigated in patients with bone metastasis from hepatocellular carcinoma (HCC) treated with radiotherapy (RT).

Methods

Clinical data of 302 patients receiving RT for 511 bone metastases from HCC between 2005 and 2018 were reviewed. Data on absolute lymphocyte count (ALC) from pre-RT to 12 months post-RT were collected. Severe TRL was defined as ALC <500 cells/mm³ and evaluated using ALC 2 months after initiating RT. Factors associated with TRL were analyzed, which include the amount of active bone marrow within the RT field. The amount of active bone marrow included in the RT field was calculated as the product of the percentage of the bo

SUBMITTER: Park S 

PROVIDER: S-EPMC6883451 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature