Proenkephalin a 119-159 (penKid) - a novel biomarker for acute kidney injury in sepsis: an observational study.

ABSTRACT: BACKGROUND:Sepsis is a leading cause of death worldwide and a major challenge for physicians to predict and manage. Proenkephalin A 119-159 (penKid) is a reliable surrogate marker for the more unstable endogenous opioid peptide enkephalin, which has previously been shown to predict both acute and chronic kidney disease. The aim of this prospective observational study was to assess penKid as a predictor of acute kidney injury (AKI), multi-organ failure and mortality in sepsis among unselected sepsis patients presenting to the emergency department (ED). METHOD:We enrolled 644 patients consecutively during office-hours (6 AM-6 PM) between December 1, 2013 and February 1, 2015. Fifty-six patients were excluded due to incomplete data. We measured penKid in 588 adult patients (patients under 18 

SUBMITTER: Rosenqvist M 

PROVIDER: S-EPMC6883703 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature