Ontology highlight
ABSTRACT:
SUBMITTER: Federici G
PROVIDER: S-EPMC6883719 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Federici Giulia G Varricchio Lilian L Martelli Fabrizio F Falchi Mario M Picconi Orietta O Francescangeli Federica F Contavalli Paola P Girelli Gabriella G Tafuri Agostino A Petricoin Emanuel F EF Mazzarini Maria M Zeuner Ann A Migliaccio Anna Rita AR
Frontiers in oncology 20191122
Although stem cell factor (SCF)/cKIT interaction plays key functions in erythropoiesis, cKIT signaling in human erythroid cells is still poorly defined. To provide new insights into cKIT-mediated erythroid expansion in development and disease, we performed phosphoproteomic profiling of primary erythroid progenitors from adult blood (AB), cord blood (CB), and Polycythemia Vera (PV) at steady-state and upon SCF stimulation. While AB and CB, respectively, activated transient or sustained canonical ...[more]