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Translation of peptidoglycan metabolites into immunotherapeutics.

ABSTRACT: The discovery of defined peptidoglycan metabolites that activate host immunity and their specific receptors has revealed fundamental insights into host-microbe recognition and afforded new opportunities for therapeutic development against infection and cancer. In this review, we summarise the discovery of two key peptidoglycan metabolites, ?-d-glutamyl-meso-diaminopimelic acid (iE-DAP) and muramyl dipeptide and their respective receptors, Nod1 and Nod2, and review progress towards translating these findings into therapeutic agents. Notably, synthetic derivatives of peptidoglycan metabolites have already yielded approved drugs for chemotherapy-induced leukopenia and paediatric osteosarcoma; however, the broad effects of peptidoglycan metabolites on host immunity suggest additional translational opportunities for new therapeutics towards other cancers, microbial infections and inflammatory diseases.

SUBMITTER: Griffin ME

PROVIDER: S-EPMC6883908 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Translation of peptidoglycan metabolites into immunotherapeutics.

Griffin Matthew E ME Hespen Charles W CW Wang Yen-Chih YC Hang Howard C HC

Clinical & translational immunology 20191129 12

The discovery of defined peptidoglycan metabolites that activate host immunity and their specific receptors has revealed fundamental insights into host-microbe recognition and afforded new opportunities for therapeutic development against infection and cancer. In this review, we summarise the discovery of two key peptidoglycan metabolites, γ-d-glutamyl-<i>meso</i>-diaminopimelic acid (iE-DAP) and muramyl dipeptide and their respective receptors, Nod1 and Nod2, and review progress towards transla ...[more]

PMID: 31798878

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