Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC6884002 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Chen Si S Liu Hong H Wu Qian-Qian QQ Xu Shu-Jun SJ Li Wei-Guo WG Chen Teng T Li Chao C Ma Xiang-Yu XY Xu Shuo S Liu Yi-Ming YM
Frontiers in neurology 20191122
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease (PD). The G2385R variant of <i>LRRK2</i> is a risk factor for PD in Han Chinese individuals. We retrospectively compared the clinical outcomes of STN-DBS surgery between PD Han Chinese <i>G2385R</i> variant carriers and non-carriers. Fifty-seven PD patients with bilateral STN-DBS were enrolled, including 8 G2385R+ variant carriers (G2385R+ group) and 49 non-carriers (G2385R- g ...[more]