Ontology highlight
ABSTRACT:
SUBMITTER: Donovan DA
PROVIDER: S-EPMC6884087 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Cell reports 20191101 8
Regulation of chromatin structure is essential for controlling access of DNA to factors that require association with specific DNA sequences. Here we describe the development and validation of engineered chromatin remodeling proteins (E-ChRPs) for inducing programmable changes in nucleosome positioning by design. We demonstrate that E-ChRPs function both in vitro and in vivo to specifically reposition target nucleosomes and entire nucleosomal arrays. We show that induced, systematic positioning ...[more]