Neutralization and beyond: Antibodies and HIV-1 acquisition.
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ABSTRACT:
SUBMITTER: Thomas AS
PROVIDER: S-EPMC6884343 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Neutralization and beyond: Antibodies and HIV-1 acquisition.
Thomas Allison S AS Ghulam-Smith Melissa M Sagar Manish M
Current Topics In Virology 20180101
It is widely accepted that an effective HIV-1 preventative vaccine must elicit antibodies that can block virus acquisition. Although, anti-HIV-1 broadly neutralizing antibodies (bnAbs) have been isolated, unfortunately, no vaccine immunogens have been designed that can elicit these bnAbs in uninfected at-risk individuals. Some studies have suggested that other antibody functionalities, besides neutralization, such as antibody-dependent cellular cytotoxicity (ADCC), may prevent HIV-1 acquisition. ...[more]
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