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Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease.

ABSTRACT: An increase of heart rate to physical or mental stress reflects the ability of the autonomous nervous system and the heart to respond adequately. Hyperventilation is a user-controlled breathing maneuver that has a significant impact on coronary function and hemodynamics. Thus, we aimed to investigate if the heart rate response to hyperventilation (HRR_HV) can provide clinically useful information. A pooled analysis of the HRR_HV after 60?s of hyperventilation was conducted in 282 participants including healthy controls; patients with heart failure (HF); coronary artery disease (CAD); a combination of both; or patients suspected of CAD but with a normal angiogram. Hyperventilation significantly increased heart rate in all groups, although healthy controls aged 55 years and older (15?±?9?bpm) had a larger HRR_HV than each of the disease groups (HF: 6?±?6, CAD: 8?±?8, CAD+/HF+: 6?±?4, and CAD-/HF-: 8?±?6?bpm, p?HV may serve as an easily measurable additional marker of cardiovascular health. Future studies should test its diagnostic potential as a simple, inexpensive pre-screening test to improve patient selection for other diagnostic exams.

SUBMITTER: Hawkins SM

PROVIDER: S-EPMC6884614 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease.

Hawkins Selwynne M SM Guensch Dominik P DP Friedrich Matthias G MG Vinco Giulia G Nadeshalingham Gobinath G White Michel M Mongeon Francois-Pierre FP Hillier Elizabeth E Teixeira Tiago T Flewitt Jacqueline A JA Eberle Balthasar B Fischer Kady K

Scientific reports 20191129 1

An increase of heart rate to physical or mental stress reflects the ability of the autonomous nervous system and the heart to respond adequately. Hyperventilation is a user-controlled breathing maneuver that has a significant impact on coronary function and hemodynamics. Thus, we aimed to investigate if the heart rate response to hyperventilation (HRR<sub>HV</sub>) can provide clinically useful information. A pooled analysis of the HRR<sub>HV</sub> after 60 s of hyperventilation was conducted in ...[more]

PMID: 31784617

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Project description:PurposeWe evaluated the associations between accelerometer-estimated physical activity (PA) intensity and heart rate variability (HRV) and examined mediation of these associations by glycemic control indices and other cardiovascular disease risk factors.MethodsData were from 1668 participants (X[Combining Overline]age = 45.9 ± 3.5 yr, 58.0% female, 39.9% black) who participated in year 20 (2005-2006) of the Coronary Artery Risk Development in Young Adults Fitness Study. The ActiGraph 7164 estimated participants' mean minutes per day of vigorous-intensity PA (VPA), moderate-intensity PA (MPA), and light-intensity PA (LPA) over 7 d. Three sequential 10-s 12-lead ECG strips were used to derive standard deviation of all normal RR intervals (SDNN) and root mean square of all successive RR intervals (rMSSD) HRV. Mediators representing glycemic control indices included fasting glucose, fasting insulin, and 2-h oral glucose tolerance, with other mediators being traditional cardiovascular disease risk factors. Multiple linear regression assessed independent associations of PA intensity with HRV per 1-SD. Mediation analyses computed the proportion of the PA-HRV association attributable to physiological mediators.ResultsParticipants averaged 2.7 ± 6.2 min·d, 33.0 ± 22.0 min·d, and 360.2 ± 83.8 min·d of VPA, MPA, and LPA, respectively, with mean values for SDNN (32.6 ± 22.4 ms) and rMSSD (34.0 ± 24.8 ms) similar. After adjustment for demographic and lifestyle behaviors, VPA was associated with both HRV metrics (SDNN: std beta = 0.06 [0.03, 0.10]; rMSSD: std beta = 0.08 [0.05, 0.12]) and LPA with rMSSD only (std beta = 0.05 [0.01, 0.08]). Fasting insulin and glucose mediated 11.6% to 20.7% of the association of VPA and LPA with HRV, with triglycerides also potentially mediating these associations (range, 9.6%-13.4%).ConclusionsAccelerometer-estimated VPA was associated with higher (i.e., improved) HRV. Light-intensity PA also demonstrated a positive association. Mediation analyses suggested these associations may be most attributable to glucose-insulin dynamics.

Dataset Information

Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease.

Publications

Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease.

Similar Datasets

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