Ontology highlight
ABSTRACT:
SUBMITTER: Ballester M
PROVIDER: S-EPMC6884617 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Ballester Maria M Sentandreu Enrique E Luongo Giovanna G Santamaria Ramon R Bolonio Miguel M Alcoriza-Balaguer Maria Isabel MI Palomino-Schätzlein Martina M Pineda-Lucena Antonio A Castell Jose J Lahoz Agustin A Bort Roque R
Scientific reports 20191129 1
Human dermal fibroblasts can be reprogrammed into hepatocyte-like (HEP-L) cells by the expression of a set of transcription factors. Yet, the metabolic rewiring suffered by reprogrammed fibroblasts remains largely unknown. Here we report, using stable isotope-resolved metabolic analysis in combination with metabolomic-lipidomic approaches that HEP-L cells mirrors glutamine/glutamate metabolism in primary cultured human hepatocytes that is very different from parental human fibroblasts. HEP-L cel ...[more]