Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC6885115 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Xu Jiean J Yang Qiuhua Q Zhang Xiaoyu X Liu Zhiping Z Cao Yapeng Y Wang Lina L Zhou Yaqi Y Zeng Xianqiu X Ma Qian Q Xu Yiming Y Wang Yong Y Huang Lei L Han Zhen Z Wang Tao T Stepp David D Bagi Zsolt Z Wu Chaodong C Hong Mei M Huo Yuqing Y
The Journal of endocrinology 20190801 2
Insulin resistance-related disorders are associated with endothelial dysfunction. Accumulating evidence has suggested a role for adenosine signaling in the regulation of endothelial function. Here, we identified a crucial role of endothelial adenosine kinase (ADK) in the regulation of insulin resistance. Feeding mice with a high-fat diet (HFD) markedly enhanced the expression of endothelial Adk. Ablation of endothelial Adk in HFD-fed mice improved glucose tolerance and insulin sensitivity and de ...[more]