Dataset Information

Synergism of Adipocytokine Profile and ADIPOQ/TNF-? Polymorphisms in NAFLD-associated MetS Predict Colorectal Liver Metastases Outgrowth.

ABSTRACT: BACKGROUND/AIM:The aim of this study was to evaluate whether the altered profile of adipocytokine and genetic fingerprint in NAFLD-associated metabolic syndrome "cluster" represents synergistic risk factors predicting onset of liver colorectal cancer metastases. MATERIALS AND METHODS:A total of 165 colorectal cancer patients were enrolled, 56,3% were with metabolic syndrome/NAFLD. Serum samples were assayed for ADIPOQ, leptin and TNF-a levels by ELISA. ADIPOQ rs266729 C/G and TNF-308 A/G genotypes were analyzed in DNA isolated from whole blood. RESULTS:Reduction in adiponectin levels and increase in leptin and TNF-? was shown in patients with liver metastases. This trend was influenced by BMI, MetS/NAFLD, and insulin resistance. ADIPOQ G rs266729 and TNF- 308 A allele are associated with obesity, MetS/NAFLD and insulin resistance. ADIPOQ CG/GG and GA/AA TNF-alpha genotypes confer susceptibility to liver metastases. CONCLUSION:Obesity and hepatic steatosis significantly favor the development of colorectal cancer liver metastases and the individual adipocytokines genetic profile may play an important predictive role.

SUBMITTER: Divella R

PROVIDER: S-EPMC6885361 | biostudies-literature | 2019 Nov-Dec

REPOSITORIES: biostudies-literature

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Synergism of Adipocytokine Profile and <i>ADIPOQ/TNF-α</i> Polymorphisms in NAFLD-associated MetS Predict Colorectal Liver Metastases Outgrowth.

Divella Rosa R Daniele Antonella A DE Luca Raffaele R Mazzocca Antonio A Ruggieri Eustachio E Savino Eufemia E Casamassima Porzia P Simone Michele M Sabba Carlo C Paradiso Angelo A

Cancer genomics & proteomics 20191101 6

<h4>Background/aim</h4>The aim of this study was to evaluate whether the altered profile of adipocytokine and genetic fingerprint in NAFLD-associated metabolic syndrome "cluster" represents synergistic risk factors predicting onset of liver colorectal cancer metastases.<h4>Materials and methods</h4>A total of 165 colorectal cancer patients were enrolled, 56,3% were with metabolic syndrome/NAFLD. Serum samples were assayed for ADIPOQ, leptin and TNF-a levels by ELISA. ADIPOQ rs266729 C/G and TNF- ...[more]

PMID: 31659105

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Dataset Information

Synergism of Adipocytokine Profile and ADIPOQ/TNF-? Polymorphisms in NAFLD-associated MetS Predict Colorectal Liver Metastases Outgrowth.

Publications

Synergism of Adipocytokine Profile and <i>ADIPOQ/TNF-α</i> Polymorphisms in NAFLD-associated MetS Predict Colorectal Liver Metastases Outgrowth.

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