PRIMA-1MET Induces Cellular Senescence and Apoptotic Cell Death in Cholangiocarcinoma Cells.
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ABSTRACT:
SUBMITTER: Piyawajanusorn C
PROVIDER: S-EPMC6885363 | biostudies-literature | 2019 Nov-Dec
REPOSITORIES: biostudies-literature
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PRIMA-1<sup>MET</sup> Induces Cellular Senescence and Apoptotic Cell Death in Cholangiocarcinoma Cells.
Piyawajanusorn Chayanit C Kittirat Yingpinyapat Y Sa-Ngiamwibool Prakasit P Titapun Attapol A Loilome Watcharin W Namwat Nisana N
Cancer genomics & proteomics 20191101 6
<h4>Background/aim</h4>This study examined the in vitro effects of the bile duct cancer drug PRIMA-1<sup>MET</sup> on cholangiocarcinoma (CCA) cell growth to determine its potential usefulness in CCA therapy.<h4>Materials and methods</h4>The effect of this drug on the expression of senescent markers (p16<sup>INK4A</sup> and p21) and the phosphorylation of p53 was investigated, as was the association between senescent markers and the patients' clinicopathological data.<h4>Results</h4>PRIMA-1<sup> ...[more]
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