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Presence of mEGFR ctDNA predicts a poor clinical outcome in lung adenocarcinoma.

ABSTRACT: BACKGROUND:Circulating tumor DNA (ctDNA) is a biomarker for the selection of target agents in various malignancies. In this study, we examined the effect of ctDNA presence on the response to EGFR-tyrosine kinase inhibitor (TKI) and on the prognosis in lung adenocarcinoma. METHODS:ctDNA of EGFR-TKI sensitizing mutations (mEGFR), L858R substitution and Exon 19 deletion (E19d) mutation, was evaluated using droplet digital PCR (ddPCR) in 81 patients with lung adenocarcinoma which harbored mEGFR in the corresponding tumor tissues. RESULTS:The study recruited lung cancer patients at various stages, and the sensitivity, specificity, and area under the curve (AUC) of mEGFR ctDNA detection by ddPCR were 40.0%, 88.5%, and 0.68, respectively. It showed higher sensitivity (75.0% vs. 10.0%) and AUC (0.83 vs. 0.49) in the advanced stages of lung adenocarcinoma compared with the early stages and the number of metastases and the fractional abundance of mEGFR ctDNA showed a strong correlation (? = 0.516; P?

SUBMITTER: Kim T 

PROVIDER: S-EPMC6885440 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Presence of mEGFR ctDNA predicts a poor clinical outcome in lung adenocarcinoma.

Kim Taehee T   Kim Eun Young EY   Lee Sang Hoon SH   Kwon Do Sun DS   Kim Arum A   Chang Yoon Soo YS  

Thoracic cancer 20191024 12

<h4>Background</h4>Circulating tumor DNA (ctDNA) is a biomarker for the selection of target agents in various malignancies. In this study, we examined the effect of ctDNA presence on the response to EGFR-tyrosine kinase inhibitor (TKI) and on the prognosis in lung adenocarcinoma.<h4>Methods</h4>ctDNA of EGFR-TKI sensitizing mutations (mEGFR), L858R substitution and Exon 19 deletion (E19d) mutation, was evaluated using droplet digital PCR (ddPCR) in 81 patients with lung adenocarcinoma which harb  ...[more]

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