Ontology highlight
ABSTRACT:
SUBMITTER: Narimani M
PROVIDER: S-EPMC6885567 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Blood and lymphatic cancer : targets and therapy 20191127
<h4>Introduction</h4>Human Baculoviral inhibitor of apoptosis repeat-containing 5 (<i>BIRC5</i>) which encodes survivin exhibits multiple biological activities, such as cell proliferation and apoptosis. Survivin is overexpressed in numerous malignant diseases including acute myeloid leukemia (AML). Recent studies have shown that the CRISPR/Cas9 nuclease-mediated gene-editing systems are suitable approach's for editing or knocking out various genes including oncogenes.<h4>Methods and materials</h ...[more]