Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC6885611 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Yang Xu X Yamazaki Hajime H Yamakoshi Yasuo Y Duverger Olivier O Morasso Maria I MI Beniash Elia E
The Journal of biological chemistry 20191018 48
A highly specialized cytoskeletal protein, keratin 75 (K75), expressed primarily in hair follicles, nail beds, and lingual papillae, was recently discovered in dental enamel, the most highly mineralized hard tissue in the human body. Among many questions this discovery poses, the fundamental question regarding the trafficking and secretion of this protein, which lacks a signal peptide, is of an utmost importance. Here, we present evidence that K75 is expressed during the secretory stage of ename ...[more]