Haplotype analysis of ADAM33 polymorphisms in asthma: A pilot study.

ABSTRACT:

Background & objectives

ADAM33 is implicated as a potentially strong candidate gene for asthma and bronchial hyper-responsiveness. Many polymorphisms of ADAM33 have been studied along with ADAM33 expression in various cells of the lungs. Haplotype analysis also showed association with asthma in different populations across the world. Therefore, the aim of this study was to perform a comprehensive screening of ADAM33 polymorphisms in adult patients with asthma.

Methods

Thirty five polymorphisms of ADAM33 were genotyped in 55 patients with asthma and 53 controls. The association of single nucleotide polymorphisms (SNPs) and haplotypes with phenotypes of asthma was analysed.

Results

The genotype, minor allele frequency, odds ratio and Hardy-Weinberg equilibrium did not s

SUBMITTER: Vishweswaraiah S 

PROVIDER: S-EPMC6886134 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature