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Brain activation to cannabis- and alcohol-related words in alcohol use disorder.

ABSTRACT: Cannabis abuse commonly co-occurs with alcohol use disorder (AUD). With increased acceptance and accessibility to cannabis in the US, it is imperative to understand the psychological and neural mechanisms of concurrent alcohol and cannabis use. We hypothesized that neural alcohol-cue conditioning may extent to other drug-related stimuli, such as cannabis, and underwrite the loss of control over reward-driven behavior. Task-activated fMRI examined the neural correlates of alcohol- and cannabis-related word cues in 21 abstinent AUD and 18 control subjects. Relative to controls, AUD showed behavioral attentional biases and frontal hypoactivation to both alcohol- and cannabis-related words. This cue-elicited prefrontal hypoactivation was related to higher lifetime alcohol consumption (p_corrected?

SUBMITTER: Muller-Oehring EM

PROVIDER: S-EPMC6886708 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Brain activation to cannabis- and alcohol-related words in alcohol use disorder.

Müller-Oehring Eva M EM Le Berre Anne-Pascale AP Serventi Matthew M Kalon Ember E Haas Amie L AL Padula Claudia B CB Schulte Tilman T

Psychiatry research. Neuroimaging 20191102

Cannabis abuse commonly co-occurs with alcohol use disorder (AUD). With increased acceptance and accessibility to cannabis in the US, it is imperative to understand the psychological and neural mechanisms of concurrent alcohol and cannabis use. We hypothesized that neural alcohol-cue conditioning may extent to other drug-related stimuli, such as cannabis, and underwrite the loss of control over reward-driven behavior. Task-activated fMRI examined the neural correlates of alcohol- and cannabis-re ...[more]

PMID: 31715379

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