Ontology highlight
ABSTRACT:
SUBMITTER: Mant CT
PROVIDER: S-EPMC6886721 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Mant Colin T CT Jiang Ziqing Z Gera Lajos L Davis Tim T Nelson Kirsten L KL Bevers Shaun S Hodges Robert S RS
Journal of medicinal chemistry 20190321 7
We have designed de novo and synthesized ten 26-residue D-conformation amphipathic α-helical cationic antimicrobial peptides (AMPs), seven with "specificity determinants", which provide specificity for prokaryotic cells over eukaryotic cells. The ten AMPs contain five or six positively charged residues (d-Arg, d-Lys, d-Orn, l-Dab, or l-Dap) on the polar face to understand their role in hemolytic activity against human red blood cells and antimicrobial activity against seven Acinetobacter baumann ...[more]