Association between dairy intake and fracture in an Australian-based cohort of women: a prospective study.

ABSTRACT: OBJECTIVE:Given the inconsistent evidence on dairy consumption and risk of fracture, we assessed the association between milk/total dairy consumption and major osteoporotic fracture (MOF) in women from the Geelong Osteoporosis Study (GOS). METHODS:Women aged ?50?years (n=833) were followed from baseline (1993-1997) to date of first fracture, death or 31 December 2017, whichever occurred first. Dairy consumption was assessed by self-report at baseline and the follow-up phases. MOFs (hip, forearm, clinical spine and proximal humerus) were confirmed radiologically. Multivariable-adjusted Cox proportional hazard models were used to determine associations between milk/total dairy (milk, cheese, yoghurt, ice cream) consumption and MOFs. Cross-sectional associations between milk/total dairy consumption and serum high-sensitivity C reactive protein (hsCRP), C-terminal telopeptide (CTx) and procollagen type 1 N-terminal propeptide (P1NP) at baseline were investigated using multivariable linear regression. RESULTS:During follow-up (11?507 person-years), 206 women had an MOF. Consuming >500?mL/d of milk was not significantly associated with increased HR for MOF. Non-milk (1.56; 95%?CI 0.99 to 2.46) drinkers and consumption of ?800?g/d total dairy (1.70; 95%?CI 0.99 to 2.93) had marginally higher HR for MOF compared with consuming <250?mL/d of milk and 200-399?g/d of total dairy, respectively. Milk consumption was inversely associated with serum hsCRP and CTx, but total dairy consumption was not associated with these serum markers. CONCLUSION:Higher milk consumption did not increase the risk for MOF in older women. However, a trend for increased MOF was detected in zero milk and higher total dairy consuming women.

SUBMITTER: Aslam H 

PROVIDER: S-EPMC6887043 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature